Statistics & Analytics
Dataset release 2026-08-14 00:00 UTC — 278 affinity measurements linking 179 compounds to 171 RNA targets.
Binding Affinity
Distribution and summary of measured RNA–ligand binding strengths across the database.
pKd Distribution
Distribution of binding strengths across all curated RNA–ligand entries. Higher pKd indicates tighter binding (lower Kd). Bar colors follow the site-wide affinity color scale.
Distribution of binding strengths across all curated RNA–ligand entries. Higher pKd indicates tighter binding (lower Kd). Bar colors follow the site-wide affinity color scale.
Experimental methods to determine binding affinity values
Kd values were measured using techniques such as SPR, ITC, and fluorescence-based assays; methods with fewer than five entries are grouped as “Others.”
Kd values were measured using techniques such as SPR, ITC, and fluorescence-based assays; methods with fewer than five entries are grouped as “Others.”
Measurement Temperature (K)
Histogram of assay temperatures in kelvin, when reported in the source publications.
Histogram of assay temperatures in kelvin, when reported in the source publications.
RNA Targets & Binding Pockets
Experimental structures, resolution, target classification, sequence length, and nucleotide composition at ligand-binding sites.
Structure Method
Experimental technique used to determine the deposited PDB structure (X-ray, cryo-EM, NMR, etc.).
Experimental technique used to determine the deposited PDB structure (X-ray, cryo-EM, NMR, etc.).
Resolution Distribution (Å)
Distribution of crystallographic or cryo-EM resolution values for structures where resolution is reported. Lower values indicate higher detail.
Distribution of crystallographic or cryo-EM resolution values for structures where resolution is reported. Lower values indicate higher detail.
RNA Class Distribution
Functional classification of RNA targets in the dataset (riboswitch, aptamer, rRNA, etc.).
Functional classification of RNA targets in the dataset (riboswitch, aptamer, rRNA, etc.).
Pocket Nucleotide Composition
Percentage of adenine, uracil, guanine, and cytosine among all pocket residues (within 5 Å of the ligand) summed across the dataset.
Percentage of adenine, uracil, guanine, and cytosine among all pocket residues (within 5 Å of the ligand) summed across the dataset.
Top 10 RNA Targets by Binding Strength
RNA targets ranked by the strongest pKd among their curated complexes in ARIEL.
RNA targets ranked by the strongest pKd among their curated complexes in ARIEL.
Ligand Physicochemistry
Molecular properties and structure–activity relationships.
Molecular Weight Distribution
Histogram of ligand molecular weights (Da) across unique ligands in the dataset.
Histogram of ligand molecular weights (Da) across unique ligands in the dataset.
LogP (ALOGP) Distribution
Distribution of OpenEye ALOGP lipophilicity values computed from RCSB canonical SMILES.
Distribution of OpenEye ALOGP lipophilicity values computed from RCSB canonical SMILES.
QED Distribution
Quantitative Estimate of Drug-likeness (0–1).
Quantitative Estimate of Drug-likeness (0–1).
Top 5 Ligands Ranked by Strongest Affinity
Ligands with the highest best pKd among their RNA–ligand complexes in the dataset.
Ligands with the highest best pKd among their RNA–ligand complexes in the dataset.