ARIEL
Affinity Resource for Interactions of RNA & Ligands
Experimentally measured RNA–ligand binding affinities, resolved to 3D structure.
An open, manually curated database pairing each experimental dissociation constant (Kd) with its deposited 3D structure — searchable, downloadable, and updated timely. Freely accessible to all users, including commercial use, under an open-access license.
- Open access
- Free for commercial use
- Structure-resolved Kd
- Updated timely
Search database
Query 278 curated RNA–ligand complexes by structure, affinity, ligand chemistry, and RNA sequence.
Complete search form
Filter by PDB ID/Extended PDB ID, CCD ligand IDs, compound names, pKd range, Kd methods, resolution, molecular weight, RNA class, and RNA sequence — with tabbed search for complexes, ligands, and targets.
Start with common filters
Filter RNA–ligand complexes by PDB ID/Extended PDB ID, CCD ligand ID, RNA target name, and pKd.
Explore the resource
Browse complexes
Every RNA–ligand pair with its experimental Kd, method, and source structure.
AnalysisStatistics
Affinity distributions, chemical space, and coverage across the curated dataset.
ReferenceHelp & field reference
Field definitions, measurement methods, and curation conventions for every table.
MethodsAbout & citation
Data sources, curation methodology, licensing, and how to cite ARIEL.